Recently, U.S. researchers announced their latest study: those in vivo existence of a particular homozygous populations, a greater risk of cancer.
Cleveland Clinic Foundation, a research team led by卡里斯博士studies have shown that: Compared with the control group, cancer patients with germline heterozygous occurrence rate is very low. Thus, germline homozygosity in cancer susceptibility is related to the need to study has become one of the issues.
The group of several hundred people with three different solid tumor patients and control groups studied. The researchers of the reproductive system and the corresponding tumor DNA (tumor DNA from 385 of these cancer patients, including 147 with breast cancer, 116 with prostate cancer, 122 with head and neck cancer) were analyzed. The results showed that: compared with control group, taken from three different solid tumors showed genetic markers in the Special Branch germline homozygosity high rates of these cancers relevant. Another important point is that researchers in a different type of solid tumor (lung cancer) in independently verify their conclusions.
Relevant personnel also said that, if you know those same sites of germline homozygosity / heterozygosity of the relative frequency of words, through further research and fine structural analysis, it is possible to use these data to predict in a given tumor loss of a specific gene locus heterozygosity possibilities
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